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Creative Biolabs Offers On-Stop PROTAC Discovery Solutions for Drug Development

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Creative Biolabs Offers On-Stop PROTAC Discovery Solutions for Drug Development

June 30
18:16 2021
Cancer is a major burden of disease worldwide. Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it. Recently, Creative Biolabs announced that its updated PROTAC technology platform can provide research tools for novel molecule drugs to assist in the discovery of cancer drugs.

New York, USA – June 30, 2021 – Drug treatment of cancer typically uses antibodies, siRNAs, and small molecules to block the activity of oncogenic proteins. However, drug resistance occurs when a small-molecule drug is frequently used. Other molecules have difficulties in cell permeability and drug delivery. The advent of PROTAC technology has largely solved the problems of traditional anti-cancer treatments and opened a new chapter for novel drug development.

Proteolysis targeting chimera (PROTAC) is a strategy that utilizes the ubiquitin-protease system to target a specific protein and induce its degradation in the cell. This technology has absolute advantages because it can not only efficiently degrade proteins to avoid drug resistance caused by overexpression of target proteins, but also unlock parts of proteins that have traditionally been considered “undruggable”. As a global leader in the field of biotechnology, Creative Biolabs has established a professional PROTAC technology platform, providing a range of custom services based on PROTAC technology, covering all aspects from ligand design, screening, biological evaluation to PROTAC optimization, to help customers effectively develop new anticancer drugs.

“Cancers are usually triggered by tumorigenic proteins. A common therapeutic approach is therefore to inhibit the function of these proteins with drugs,” said a scientist at Creative Biolabs. “BRD4-target PROTAC has emerged as a promising therapeutic target in multiple cancer types, which contributes to the development and maintenance of a majority of human cancers, providing an alternative strategy for targeting oncoproteins that are difficult to inhibit with conventional strategies.”

Treatment with BRD4 inhibitors can lead to BRD4 protein accumulation, together with the reversible nature of inhibitors binding to BRD4, which may limit the efficacy of BRD4 inhibitors. To address these problems, a protein degradation strategy based on the PROTAC technology has been developed to target BRD4 recently. These BRD4 PROTAC approaches have shown great potential for reducing cancer cell viability, opening a new direction for the discovery of anti-cancer drugs.

With years of experience in the bioscience industry, Creative Biolabs is confident in presenting a comprehensive set of services to develop ideal PROTACs for clients around the world, to assist their research from development to pre-clinical trials. In particular, Creative Biolabs offers a variety of ligand designs targeting BRD4, including small molecules, peptides, proteins, antibodies, etc.

About Creative Biolabs

Creative Biolabs is a global, science-led biological company that focuses on drug discovery for over ten years. The company has developed a cutting-edge PROTAC technology platform to provide an integrated package of one-stop PROTAC-based drug discovery solutions for researchers to accelerate the discovery of candidate molecules that will ultimately be used to treat and cure disease.

Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States

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